Alginate-Based Nanocapsular Antineoplastic Drug Delivery System By Pneumatic Nebulization
This work is an attempt to develop a generalized upgradable bench top level technology for nanocapsulation of antineoplastic drug substances. Methotrexate was selected as a model drug and calcium alginate was used as a coating material. A nebulizer head was so designed as to atomize a drug-polymer microemulsion directly into calcium chloride cross linker media. Nanocapsules thus formed were compared with those produced by in situ gelling technique. Control of various process parameters resulted in the development of superior drug nanocapsules by pneumatic nebulization technique with good yield.