Abstract

An extractive econometric method for the determination of dothiepin hydrochloride from pharmaceutical preparations.

Author(s): RT Sane, RM Kothurkar, KD Ladage, RV Tendolkar, DP Gangal
S.P. Mahdali's TDM Laboratory, Scheme 6, Road No. 15, Sion-Koliwada, Sion (E), Bombay-22,

Correspondence Address:
R T Sane S.P. Mahdali's TDM Laboratory, Scheme 6, Road No. 15, Sion-Koliwada, Sion (E), Bombay-22

An extractive colorimetric method for the determination of dothiepin hydrochloride from pharmaceutical preparations is described. The method is based on the formation of ion-pair complexes of the drug with reagents like bromophenol blue (BPB), bromothymol blue (BTB), bromocresol purple (BCP) and bromophenol red (BPR) in acidic medium. The ion-pair complexes formed are quantitatively extracted in chloroform. The method is statistically validated and is found to be precise and accurate.