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Abstract

Antihepatotoxic Activity Of Euphorbia Antisyphilitica

Author(s): S Saraf, V. K Dixit, G. K Patnaik, S. C Tripathi

A medicinally important species of Euphorbiaceae was collected from the tribal locality and cultivated in medicinal plant garden of Dr. H.S. Gour University Sagar. It was identified as Euphorbia antisyphilitica. The ethanolic extract of the aerial parts of the plant has LD50 of more than 1g/Kg in mice. Petroleum ether and ethanolic extracts were tested for antihepatotoxic activity against thiacetamide and CCI4 induced liver damage in rats. The active ethanolic extract was fractionated into chloroform soluble and insoluble fractions. The chloroform insoluble fraction was found to be active. Antihepatotoxic activity was evaluated using histopathological and serum parameters.