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Abstract

Antiinflammatory Activity Of Some New 3-Substituted-4-Amino-5-Mercapto-4(H)-1,2,4-Triazoles

Author(s): M. B Talawar, S. C Bennur, S. K Kankanwadi, P. A Patil

Certain new 3-substitued-4-amino-5-mercapto-4(H)-1,2,4-triazoles having anilinomethyl group at the 3- position have been synthesised by the reaction of 4-substitutes anilinoacetic acid hydrazides (2A-F) successively with alcoholic potassium hydroxide – carbon disulfide and hydrazine hydrate. These compounds have been characterized by spectral data and are evaluated for their antiinflammatory activity against carrageenan-induced rat paw edema and cotton pellet granuloma. All the test samples possess significant anti-inflammatory activity at 1st, 3rd, and 6th hour after the carrageenan injection. However, test sample D is devoid of anti-inflammatory activity at first hour.