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Abstract

Antimethicillin-resistant Staphylococcus aureus and Biological Activities of Metabolites from Digitaria Sanguinalis L.

Author(s): Taghreed Ibrahim1*, A. A. El-Hela2, G. T. M. Dawoud3 and Monera Zhran4
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia, 1Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, 2Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo 11371, 3Department of Phytochemistry, Medicinal Plant Center, NODCAR, 4Department of Botany, Faculty of Science (Girls), Al-Azhar University, Cairo, Egypt

Correspondence Address:
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia, Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt


The present research was aimed to evaluate the antimicrobial, antimethicillin-resistant Staphylococcus aureus, antiviral and cytotoxic activities of active fractions of the alcohol extract and seven isolated compounds from the aerial parts of Digitaria sanguinalis. Bioassay-guided fractionation of the ethanol extract of the aerial parts of Digitaria sanguinalis L. (Poaceae.) followed by several chromatographic purification steps resulted in the isolation of seven compounds. Structural elucidation of isolated compounds was achieved on the basis of spectroscopic analysis (ultraviolet, infrared, 1H and 13C nuclear magnetic resonance and mass spectra). Antimicrobial, antimethicillin-resistant Staphylococcus aureus, antiviral and cytotoxic activities were determined for the n-hexane, ethyl acetate, n-butanol fractions of the ethanol extract, in addition to the isolated compounds. Seven compounds were isolated, p-coumaric acid (1) tricin (2), p-hydroxybenzoic acid (3), stigmasterol (4), β-sitosterol-3-O-β-D-glucoside (5), tricin-7-O-β-D-glucopyranoside (6) and isoorientin (7). The results revealed that most of the isolated compounds exhibited marked antimicrobial, antiviral and cytotoxic activities, while compounds 1, 2, 5 and 6 showed a significant activity against methicillin-resistant Staphylococcus aureus. This study revealed that several fractions and isolated compounds from Digitaria sanguinalis appear to be potential new therapeutic agents, due to their significant antimicrobial, antimethicillin-resistant Staphylococcus aureus, antiviral and cytotoxic activities.



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