All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Antioxidant and antiinflammatory activity of Vitex negundo

Author(s): RR Kulkarni, AD Virkar, Priscilla D'Mello
Department of Pharmacognosy and Phytochemistry, Principal K.M. Kundnani College of Pharmacy, Plot no 23, Jote Joy Building, Rambhau Salgaonkar Marg, Cuffe Parade, Mumbai-400005, India

Correspondence Address:
Priscilla D'Mello Department of Pharmacognosy and Phytochemistry, Principal K.M. Kundnani College of Pharmacy, Plot no 23, Jote Joy Building, Mumbai-400005 India


Reactive oxygen species are implicated in various inflammatory disorders. Vitex negundo is mentioned in Ayurveda as useful in treating arthritic disorders. The present work was undertaken to evaluate the antioxidant potential and anti-inflammatory activity of the plant. The total methanol extract of the plant was standardized in terms of total polyphenols. The standardized extract in a dose of 100 mg/kg caused a comparable reduction in edema with that of diclofenac sodium (25 mg/kg) when evaluated for antiinflammatory activity by carrageenan-induced rat paw edema method. The extract also exhibited a strong free radical scavenging activity by 1,1-diphenyl-2-picrylhydrazyl method and caused a significant reduction in the formation of thiobarbituric acid reacting substances when evaluated for its lipid peroxidation inhibitory activity. The results strongly suggest that radical quenching may be one of the mechanisms responsible for its antiinflammatory activity

Full-Text | PDF

 
 
Google scholar citation report
Citations : 66710

Indian Journal of Pharmaceutical Sciences received 66710 citations as per google scholar report