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Abstract

Buccoadhesive Film Of Triamcinolone Acetonide : Development And Evaluation Of A Buccoadhesive-Erodible Carrier For Treatment Of Oral Lesions

Author(s): Javed Ali, R. K Khar, Alka Ahuja

Buccoadhesive films of triamcinolone acetonide (TA) for local delivery of the drug to the oral cavity for the treatment of oral lesions were prepared by the solvent casting technique. Different bioadhesive polymers were evaluated for film formation. Propylene glycol was used as the plasticizer while the choice of solvents was based on the type of polymer chosen. The films were characterized on the basis of their physical characteristics, bioadhesive performance, release characteristics, surface ph, folding endurance and stretchability. The optimized film exhibited an in vitro adhesion time of 3.24 hours and an in vitro release of 89.98% in 3.5 hours. The buccoadhesive films were accepted well by healthy human volunteers and no irritation of buccal mucosa was reported.