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Abstract

Camptothecine - A Novel Anticancer Agent From Tissue Cultures Of Nothapodytes Foetida

Author(s): Sundravelan, R.B Desireddy, Veeresham Ciddi

Camptothecines have a broad spectrum of antitumor activity both in vitro and in vivo and various clinical properties. Nothapodytes foetida has much higher contents of camptothecine (0.3% dry weight) and its analogs than all other botanical sources of camptothecines. This article indicates the need of systematic studies on cell cultures of Nothapodytes foetida to enhance the production of camptothecine and its analogs by employing various strategies.