Chemoprotective effect of curcumin against cyclophosphamide toxicity.
Amala Cancer Research Centre,Amala Nagar,Trichur 680 553,
K K Soudamini Amala Cancer Research Centre,Amala Nagar,Trichur 680 553
Life-span of mice treated with a chronic lethal dose of cyclophosphamide was considerably increased by the simultaneous administration of turmeric extract or curcumin (40.8 percent and 91.7 percent respectively ). Similarly leukoplnia produced by cyclophosphamide was reduced by these agents but lowered haemoglobin levels remained unaltered. Increased glutamate-pyruvate transaminase, alkaline phosphates and thiobarbituric acid- reacting material in the liver were also reduced by turmeric and curcumin.