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Abstract

Colorimetric method for the determination of piperazine in pharmaceutical formulations

Author(s): M Senthilraja
Department of Pharmaceutical Chemistry, K. M. C. H. College of Pharmacy, Kalapatti Road, Kovai Estate, Coimbatore-641 035, India

Correspondence Address:
M Senthilraja Department of Pharmaceutical Chemistry, K. M. C. H. College of Pharmacy, Kalapatti Road, Kovai Estate, Coimbatore-641 035 India E-mail: [email protected]


Piperazine and its salts are reacted with alcoholic p-benzoquinone and buffered at pH 5.4 to give a coloured product with maximum absorption at 516 nm. The piperazine base has a molar absorptivity of 0.96 × 10 4 1/mol/cm, and Beer's law is obeyed in the range of 4-20 µg/ml. When applied to two commercial preparations, the proposed method gave mean recoveries within 1%, and relative standard deviation was less than 1%.



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