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Abstract

Comparative Release Studies Of Transdermal Films Of Terbutaline Sulphate Across Various Diffusion Barriers

Author(s): S Narasimha Murthy, V Hamsa, Shyamala Bhaskaran

Transdermal films of Terbutaline Sulphate were prepared using polymers such as HPMC and Sodium CMC. The drug release was studied across various diffusion barriers that include cellophane membrane, rat abdominal skin and stratum corneum of fresh human cadaver skin. The permeation rate from various diffusion barriers were compared. The HPMC films showed a greater rate of release compared to that of Sodium CMC across all the barriers used.