Coupling Of Indomethacin To Poly (HEMA); In Vitro And Bioavailability Characterization
A polymeric pro-drug of indomethacin was synthesised. The pro-drug was evaluated for drug content and in vitro drug release behavior at pH 1.2 and 7.2. The in vitro and studies show that the drug-release takes place predominantly at the higher pH and also in a sustained manner as hypothesized. The bioavialability investigations show complete drug absorption from the polymeric pro-drug, thus showing its potential for site-specific and sustained drug delivery.