Determination of Doxazosin Mesylate in Tablets by RP-HPLC

Author(s): B Dhanya, A Suganthi, AK Sen, U Sahoo, AK Seth

A simple, precise and rapid RP-HPLC method was developed for the determination of doxazosin mesylate in pharmaceutical formulations. The method was carried out on a Chromolith RP-C18 column using a mixture of potassium phosphate buffer and methanol (40:60 v/v) and detection was done at 251 nm. The linearity range was 1-5 µg/ml. The retention time of the drug was 3.8 min. The LOD and LOQ were found to be 0.1 µg/ml and 0.5 µg/ml, respectively.

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