Development Of Sustained Release Suppositories Of Terbutaline Sulphate
Terbutaline-loaded conventional suppositories, sustained release matrix suppositories and sustained release two layered suppositories were prepared using Polyethylene glycol 4000, Drug Coat L100 and Drug Coat S100. In vitro characteristics of these suppositories were evaluated. In comparison to conventional suppositories the release of drug from sustained release matrix suppositories was gradual and extended over a period of time. On the other hand two layered suppositories produced an initial quick release followed by extended release of the drug.