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Abstract

Dissolution enhancement of ibuprofen-hydrolyzed gelatin kneaded mixtures.

Author(s): MC Gohel, MM Patel, AF Amin, SM Trivedi
Dept. of Pharm. Technology, L.M. College of Pharmacy, Navarangpura, Ahmedabad 380 009

Correspondence Address:
M C Gohel Dept. of Pharm. Technology, L.M. College of Pharmacy, Navarangpura, Ahmedabad 380 009

The objective of this investigation was to evaluate the joint effects of variables such as kneading time, amount of hydrolyzed gelatin and drying temprature on the dissolution effciency (PDE) was chosen as the response in the 2(3) full factorial design. The PDE was significantly affected by the selected variables. A polynomial equation, with interaction terms, was generated and step-wise multiple linear regression analysis was carried out to identify the key variables. The higher levels of kneading time, 10 min. and hydrolyzed geletin, 50 mg per 200 mg ibuprofen favoured the dissolution of ibuprofen from the kneaded mixture. A checkpoint was chosen to verify validity of the equation.