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Abstract

Effective And Controlled Transdermal Delivery Of Metoprolol Tartarate

Author(s): Sadhana P Gupta, S. K Jain

The present work comprises the formulation and evaluation of metoprolol tartarate transdermal drug delivery system for controlled release of drug for extended period of time. Eudragit RL and hydroxypropylmethylcellulose were used for fabrication of the matrix diffusion controlled transdermal drug delivery system. These transdermal drug delivery systems were characterized for their thickness, tensile strength and drug content. Then they were characterized for in vitro release kinetics and drug skin permeation studies. The system comprising of RL:hydroxypropylmethylcellulose in 40:60 ratio exhibited drug skin permeation 87.5 μg/h/cm2. This transdermal system was evaluated for its in vivo performance studies and compared its drug plasma profile with those obtained with oral multiple doses administered of conventional tablets of metoprolol tartarate. The transdermal drug delivery system exhibited better and constant drug plasma profile for 24 h as compared to oral administration.