All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Enhancement of intestinal absorption of few cox-2 inhibitors through interaction with ?-cyclodextrin

Author(s): Swati Rawat1, SK Jain2
1 Y. B. Chavan College of Pharmacy, Rouza Bagh, Aurangabad - 431 001, India 2 Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar - 470 003, India

Correspondence Address:
Swati Rawat Y. B. Chavan College of Pharmacy, Rouza Bagh, Aurangabad - 431 001 India E-mail: [email protected]


Complexing a drug may alter the rate and extent of drug absorption. The complex formation is very well applied in the administration of poorly water-soluble drugs. The drugs selected for the study are cyclooxygenase-2 inhibitors, are potent anti-inflammatory drugs with very low water solubility. The water solubility of these drugs was enhanced by complexing with β -cyclodextrin. In vitro absorption studies using isolated inverted bovine gut technique showed greater rate of transport of these drugs when complexed with β -cyclodextrin. The increase in the rate of transport is due to the formation of inclusion complexes with β -cyclodextrin that in turn increases the absorption. Studies also reveal that as the concentration of complexing agent increases the rate of absorption also increases proportionately. A statistical correlation was attempted between the mean percent drug dissolved at time 't' and quantity of drug absorbed at time 't/2'. When relation of in vitro drug dissolution and in vitro drug absorptions were studied, it was found that the r 2 -values for all formulations are within 0.947 to 0.997. This indicates a strong positive correlation between the in vitro drug dissolution and absorption of the drug through everted gut.



Share this