Enhancement of intestinal absorption of few cox-2 inhibitors through interaction with ?-cyclodextrin
1 Y. B. Chavan College of Pharmacy, Rouza Bagh, Aurangabad - 431 001, India 2 Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar - 470 003, India
Swati Rawat Y. B. Chavan College of Pharmacy, Rouza Bagh, Aurangabad - 431 001 India E-mail: [email protected]
Complexing a drug may alter the rate and extent of drug absorption. The complex formation is very well applied in the administration of poorly water-soluble drugs. The drugs selected for the study are cyclooxygenase-2 inhibitors, are potent anti-inflammatory drugs with very low water solubility. The water solubility of these drugs was enhanced by complexing with β -cyclodextrin. In vitro absorption studies using isolated inverted bovine gut technique showed greater rate of transport of these drugs when complexed with β -cyclodextrin. The increase in the rate of transport is due to the formation of inclusion complexes with β -cyclodextrin that in turn increases the absorption. Studies also reveal that as the concentration of complexing agent increases the rate of absorption also increases proportionately. A statistical correlation was attempted between the mean percent drug dissolved at time 't' and quantity of drug absorbed at time 't/2'. When relation of in vitro drug dissolution and in vitro drug absorptions were studied, it was found that the r 2 -values for all formulations are within 0.947 to 0.997. This indicates a strong positive correlation between the in vitro drug dissolution and absorption of the drug through everted gut.