Enhancement of the Dissolution Rate of Indomethacin by Solid Dispersions in Low-substituted Hydroxypropyl Cellulose
Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, 1Institute of Industrial Pharmacy, 2Department of Microbiology and Parasitology, Faculty of Pharmacy, Complutense University, 28040 Madrid, 3Department of Biomedical Science University of Alcalá, Ctra. Madrid-Barcelona Km. 33.6, 28871 Alcalá de Henares, Spain
Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Institute of Industrial Pharmacy, Madrid-Barcelona Km. 33.6, 28871 Alcalá de Henares, Spain, E-mail: [email protected]
In the present study, new indomethacin formulations were developed in order to enhance the indomethacin dissolution rate by preparing solid dispersions using the freeze-drying method. The degree of alterations in the crystallinity of indomethacin was assessed according to the preparation method and by the addition of low-substituted hydroxypropyl cellulose. Solid dispersions improved the dissolution rate of indomethacin. Combined use of scanning electron microscopy, X-ray powder diffraction and differential scanning calorimetry revealed the basis of the increase in dissolution rate of indomethacin when formulated as low-substituted hydroxypropyl cellulose solid dispersions.