Evaluation of antiinflammatory activity of methanol extract of Phyllanthus amarus in experimental animal models
Dept of Pharmacology, K. L. E. S's College of Pharmacy, Belgaum-590 010, India
The effects of methanol extract of Phyllanthus amarus on different phases of inflammation were examined. Investigations were performed using different phlogistic agents-induced paw edema, carrageenan-induced air-pouch inflammation and cotton pellet granuloma in rats. Methanol extract of Phyllanthus amarus significantly inhibited carrageenan, bradykinin, serotonin and prostaglandin E1-induced paw edema, but failed to inhibit the histamine-induced paw edema. Maximum inhibition was observed in prostaglandin E1-induced paw edema. In carrageenan air-pouch model, methanol extract of Phyllanthus amarus significantly reduced the volume of exudate and migration of neutrophils and monocytes. The extract significantly decreased formation of granuloma tissue in chronic inflammation model. The present study revealed that methanol extract of Phyllanthus amarus inhibits all the phases of inflammation.