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Abstract

Evaluation Of Synthesized Cross-linked Tragacanth As A Potential Disintegrant

Author(s): M. C Gohel, S. D Patel, N. K Shah, G. K Jani

Cross-linked tragacanth was prepared using epichlorhydrin. The effects of ratio of tragacanth to epichiorhydrin, temperature and time of reaction were studied. The cross-linked tragacanth was evaluated for swelling capacity, hydration capacity and moisture sorption capacity. Dispersible tablets of albendazole were prepared and evaluated. The cross-linked tragacanth exhibited superior wicking and swelling action and hence can be used as a super functional disintegrant. A simple test is proposed for measuring water uptake rate by the tablets. The results of the test showed good correlation with the disintegration time. The cross-linked tragacanth was found to be effective both in soluble lactose system and the insoluble dicalcium phosphate system.