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Abstract

Formulation And Evaluation Of Nimesulide Dispersible Tablets Using Natural Disintegrants

Author(s): G D Gupta, R S Gaud

Dispersible tablets of nimesulide (DTN) were formulated using natural substances as disintegrants such as Plantago ovata seed husk, Cassia tora (Sickle senna) and Cassia nodosa in different concentrations. Formulations were evaluated for the standards of dispersible tablets and were compared with marketed products. It was observed that all the formulations were acceptable with the reasonable limits of standards required for dispersible tablets. The study revealed that natural gums used as disintegrants were effective in low (5%) concentration.