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Abstract

Free Radical Scavenging and Anticollagenase Properties of Sargachromanol I from Myagropsis myagroides

Author(s): K. B. W. R. Kim, M. J. Kim1, S. M. Jeong and D. H. Ahn1*
Institute of Fisheries Sciences, Pukyong National University, Busan 46041, 1Department of Food Science and Technology/Institute of Food Science, Pukyong National University, Busan 48513, Republic of Korea

Correspondence Address:
Department of Food Science and Technology/Institute of Food Science, Pukyong National University, Busan 48513, Republic of Korea

The present study investigated the free radical scavenging activity and antiwrinkle properties of methanol extract, hexane, chloroform, ethyl acetate, and butanol partition fractions of Myagropsis myagroides. The methanol extract showed higher free radical scavenging (65.46 % at 0.5 mg/ml) and collagenase inhibitory activity (29.64 % at 1000 μg/ml) than the water extract (16.68 % at 0.5 mg/ml and < 5 % at 1000 μg/ml). The hexane fraction exhibited strong free radical scavenging activity (96.36 % at 0.5 mg/ml) and collagenase inhibitory activity (IC50 of 712.21 μg/ml). The hexane fraction was subjected to silica gel column chromatography, Sephadex LH-20 column chromatography, octadecyl silica Sepak cartridge, and preparative high performance liquid chromatography. Sargachromaol I was isolated, which showed strong free radical scavenging activity (95.82 % at 0.1 mg/ml) and collagenase inhibitory activity (IC50 value of 54.01 μg/ml). The potential value in preventing skin aging could be confirmed through effects of extract from Myagropsis myagroides on free radical scavenging activity and collagenase inhibitory properties.



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