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Abstract

Improvement In Flowability And Compressibility Of Ampicillin Trihydrate By Spherical Crystallization

Author(s): M.C Gohel, R.K Parikh, H Shah, R.R Dubey

Spherical crystallization was carried out by ammonia diffusion method to achieve agglomerates of primary crystals of the drug. Both agglomerated and primary crystals were subjected to measurement of micromeritic properties, compressibility, powder compaction properties and effect of crystal shape on tablet strength. Dispersible tablets of agglomerated ampicillin trihydrate were prepared using suitable excipients in formula and were evaluated for various physical parameters.The tablets gave comparable drug release with that obtained from a market product.