Improvement of dissolution rate and efficiency of nifedipine by solid dispersion in PVP-MCC and HPC-MCC.
Dept. of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003
K PR Chowdary Dept. of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003
Solid dispersin of nifedipine in combined carriers, PVP-MCC and HPC-MCC has markedly enhanced the dissolution rate and efficiency of nifedipine. About 30-37 fold increase in the dissolution rate was observed with these dispersions. The enhanced dissolution rate was due to (i) the conversion of nifedipine into amorphous form and (ii) the enhancing effect of PVP and HPC on the solubility of nifedipine. Dissolution of nifedipine from these dispersions obeyed Hixson-Crowell's cube root dissolution rate equation.