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Abstract

Indion 414 as superdisintegrant in formulation of mouth dissolve tablets

Author(s): Purnima Amin, Namita Prabhu, Anita Wadhwani

The present research paper introduces Indion 414, an ion exchange resin, as a new superdisintegrant for pharmaceutical dosage forms. Indion 414 is a pharmaceutical grade weak acid cation exchange resin. Model drugs belonging to various classes were taste masked and formulated into palatable mouth dissolve tablets. Experiments were carried out to evaluate the disintegrant property of Indion 414 by incorporating Indion 414 in fast disintegrating dosage form like mouth dissolve tablets. Indion 414 was compared with the conventional disintegrants to determine its relative efficacy.



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