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Abstract

Influence of some certified water soluble dyes, preservatives and surfactants on the bioavailability of sulphamethoxazole suspensions.

Author(s): YM Rao, D Rambhau
University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009, (A.P.)

Correspondence Address:
Y M Rao University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009, (A.P.)

Influence of some certified water soluble dyes, preservatives and surfactants on sulphamethoxazole (SMZ) bioavailability was studied on healthy human volunteers. A significant reduction in bioavailability was seen with erythrosine amongst dyes. All the preservatives used retarded the bioavailability. Least availablility was seen in the presence of benzoic acid. Anionic surfactants retarded the bioavailability to a greater extent compared to cationic surfactant.