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Abstract

Local Antiinflammatory Activity Of Jatropha Curcas L. Root In Mice

Author(s): A.M Mujumdar, A.V Misar

The roots of Jatrophe curcas were extracted successlvely with petroleum ether and methanol to investigate local antilnflammatory activity based on ethnobotanlcal lead. Methanol extract was studied against 12-O-Tetradecanoylphorbol-13-acetate, Ethyl phenylpropiolate and Arachidonic acid induced local Inflammatory response In albino mice. The methanol extract showed dose dependant local antllnflammatory activity against all these phlogestic agents. Net local antiintlammatory activity is complex mainly evident due to Inhibition of biosynthesis of prostaglandin, leukotrienes and protein kinase C and action on peripheral vascular permeability.