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Abstract

Microencapsulation Of Nifedipine - MCC Solvent Deposited System For Sustained Release

Author(s): K. P. R Chowdary, M Nagarajan, Buchi N Nalluri

Nifedipine and its solvent deposited systems on Microcrystalline Cellulose (MCC) were microencapsulated with cellulose acetate by an emulsification solvent evaporation method and the microcapsules were studied. Microcapsules containing Solvent Deposited (SD) systems as core gave sloe, sustained and complete release of nifedipine over a period of 12 hours which was not possible with microcapsules of nifedipine alone. The release depended on proportion of MCC in the SD systems used as core, coat; core ratio and size of the microcapsules. Release was diffusion controlled.