All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Multi-Fraction Absorption Model For Pharmacokinetic Analysis Of Diltiazem Tablets

Author(s): Dushyant Shah, Chandan Bhave, C. J Shishoo

Pharmacokinetic, parameters were evaluated using multi-fraction absorption model of diltiazem in mongrel dogs. A comparison was made between the conventional one compartment model (model A) and one compartment two-fraction absorption model (model B). It was found from this study that model 1 B could explain the concentration-time profile of diltiazem better compared to model 1A.