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Abstract

Neocuproine And Bathocuproine As New Reagents For Sensitive Spectrophotometric Determination Of Certain Dibenzazepine Drugs

Author(s): N. G Keshvachar, Ayesha Syeda, M. A Pasha, A. A Syed

Two new reagents, neocuproine and bathocuproine are proposed for simple, sensitive and selective spectrophotometric methods for the determination of dibenzazepine class of drugs. In the proposed method copper (lI) reacts with imipramine hydrochloride, desipramine hydrochloride, clomipramine hydrochloride, trimipramine maleate and opipramol and subsequently with neocuproine or bathocuproine in an acetic acid medium to yield yellow or orange-red colour, with maximum absorption at 460 or 480 nm, respectively. A reaction mechanism is proposed with drug - metal and reagent ratio of 1:2.