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Abstract

New Spectrophotometric Methods For The Determination Of Roxithromycin

Author(s): M. N Reddy, T. K Murthy, G. V. H Raju, J Muralikrishna, K Seshukumar, D. G Sankar

Two simple spectrophotometric methods (A and B) have been developed for the determination of roxithromycin in pure and its pharmaceutical formulations. Method A is based on the formation of a blood red coloured complex with ferric chloride and 1,10-phenanthroline with absorption maximum at 520 nm. In method B, roxithromycin forms blue coloured complex with Folin-Ciocalteu (FC) reagent in the presence of sodium carbonate exhibiting maximum absorption 'at 760 nm. The chromogens obey Beer's law in the concentration ranges of 2.5 to 40 µg/ml and 2.5 to 12.5 µg/ml for method A and B, respectively.