New Spectrophotometric Methods For The Determination Of Roxithromycin
Two simple spectrophotometric methods (A and B) have been developed for the determination of roxithromycin in pure and its pharmaceutical formulations. Method A is based on the formation of a blood red coloured complex with ferric chloride and 1,10-phenanthroline with absorption maximum at 520 nm. In method B, roxithromycin forms blue coloured complex with Folin-Ciocalteu (FC) reagent in the presence of sodium carbonate exhibiting maximum absorption 'at 760 nm. The chromogens obey Beer's law in the concentration ranges of 2.5 to 40 Âµg/ml and 2.5 to 12.5 Âµg/ml for method A and B, respectively.