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Abstract

Novel Method Of Synthesis Of Curcuminoids And Derivative Of Ibuprofen As Potent Antiinflammatory Agent

Author(s): P Jayasekhar, S. B Rao, G Santhakumari

A novel method of synthesis of curcumin-I has been successfully developed using Claisen- Dieckmann condensation where dehydrozingerone is condensed with methyl ferulate in presence of sodium ethoxide In dimethyl sulphoxide. Various curcuminoids are prepared by changing the esters and α, β-unsaturated ketones. This reaction is utilized to prepare dehydrozingerone- ibuprofen condensation product (DZIBU), a potent antiinflammatory agent. The homogenecity of compounds synthesized was established and structures were confirmed by spectral data. DZIBU exhibited powerful antiinflammatory activity on carrageenan-induced paw edema model and formaldehyde-induced arthritis model in rats. Though the analgesic activity was less when compared to that of ibuprofen, the new compound did not induce gastrointestinal side effect In animal studies.