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Abstract

Pharmacodynamic and comarative bioavailability of sustained release theophylline preparation.

Author(s): M UR Naidu, TR Kumar, KR Shekhar, R Datla
Dept. of Clinical Pharmacology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad-500 482,

Correspondence Address:
M UR Naidu Dept. of Clinical Pharmacology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad-500 482

Four sustained release theophylline preparations studied, have shown comparable bioavailability. There was difference in the peak plasma concentration. However the time to reach peak plasma concentrations was delayed with all the formulations, thus showing a sustained release property. All products produced increase in heart rate.