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Abstract

Phramacological Evaluation Of 1-(N, N-Disubstituted Aminomethyl)-3-Imino-(2-Phenyl-3,4-Dihydro-4-Oxo-Quinazolin-3-Yl) Indolin-2-Ones

Author(s): M Sarangapani, V. M Reddy

Eleven new Mannich bases of isatins were screened for potentiation of pentobarbitone-induced narcosis, anaigesic, antidepressant, anticonvulsant and H1-antihistaminic activities. The test compounds were found to exhibit a moderate analgesic activity and also to potentiate the pentobarbitone-induced narcosis. However, these compounds were found to be devoid of antidepressant, anticonvulsant and antihistaminic activities.