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Abstract

Physiochemical properties of n-hydroxymethyl chlorphensin carbamate and its kinetics of decomposition.

Author(s): A Singh, SC Chaturvedi, CJ Mbah
Dept. of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria

Correspondence Address:
A Singh Dept. of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria

The N-Hydroxymethyl chlorphensin carbonate was found to have greater water solubility, a faster intrinsic dissolution rate and lower lipophilicity than chlorphensin carbamate. It was subject to specific acid and base catalysis. Yhe rate of decomposition followed first-order kinetics.