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Abstract

Potential anticancer activity of saraca asoca extracts towards transplantable tumours in mice.

Author(s): CD Varghese, Satish, C Nair, KR Panikkar
Amala Cancer Research Centre, Amalanagar - Trichur-680 553, Kerala,

Correspondence Address:
C D Varghese Amala Cancer Research Centre, Amalanagar - Trichur-680 553, Kerala

The anticancer principle from Saraca asoca flowers indicated 50 percent cytotoxicity (in vitro) in Dalton's lymphoma ascites and Sarcoma-180 tumour cells at a concentration of 38 mug and 54 mug repectively, with no activity against normal lymphocytes but preferential activity for lymphocytes derived from leukemia patients (ALL). Tritiated thymidine incorporation studies in dicate the mechanism of action of the agent at the site of DNA synthesis.