Preparation and evaluation of chitosan-poly (acrylic acid) hydrogels as stomach specific delivery for amoxicillin and metronidazole
Department of Pharmaceutics, J. S. S. College of Pharmacy, Sri Shivarathreeshwar Nagar, Mysore-570 015, India
H G Shivakumar Department of Pharmaceutics, J. S. S. College of Pharmacy, Sri Shivarathreeshwar Nagar, Mysore-570 015 India E-mail: [email protected]
The objective of the present work was to develop stomach specific delivery systems for amoxicillin and metronidazole using chitosan and poly(acrylic acid) hydrogels. Chitosan and poly(acrylic acid) hydrogels were prepared with different composition of copolymers. The hydrogels were evaluated for swelling studies, mucoadhesive studies, in vitro drug release, scanning electron microscopic and FTIR analysis. The effect of chitosan and poly (acrylic acid) on swelling and in vitro drug release was carried out. The n value calculated was <0.5 for all the formulations containing amoxicillin and metronidazole indicating Fickian diffusion mechanism. The hydrogels with chitosan and poly (acrylic acid) ratio of 0.25:1 showed greater mucoadhesive property, maximum swelling and complete release of drugs, hence can be used for stomach specific delivery of drugs.