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Abstract

Preparation And Evaluation Of Film Forming Methacrylic Acid Copolymers

Author(s): Rita Cardoza, M. N Saraf, Mala Menon

Copolymers of methacrylic acid (MA) and 2-ethylhexyl acrylate (EHA) were synthesized by emulsion polymerization technique. These were characterized for their physicochemical properties and evaluated for their potential application in pharmaceutical film coating through free film studies and film coating tablets of diclofenac sodium. The copolymers were found to produce flexible, internally plasticized films with low water vapour permeability and adequate mechanical strength that remain insoluble below pH 5 but swell and become permeable to water at and above pH 5.The copolymers may find usefulness as film-forming agents in modified-release applications and as protective coatings against moisture. Preliminary acute oral toxicity studies in mice have indicated that these are quite safe.