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Abstract

Preparation and evaluation of solid dispersions of ibuprofen. Highly accessed article

Author(s): A Ali, SN Sharma
Dept. of Pharmaceutics, Hamdard College of Pharmacy (University of Delhi), New Delhi-110 062,

Correspondence Address:
A Ali Dept. of Pharmaceutics, Hamdard College of Pharmacy (University of Delhi), New Delhi-110 062

Solid dispersions of ibuprofen were prepared by fusion using PEG 4000, PEG 6000, mannitol, urea, sorbitol, dextrose, sucrose and their mixtures as carriers in (1;1). Interaction/stability of the drug with carriers in solid dispersions was tested by UV scanning, TLC and Infra-red analysis.q. The results reveal that solid dispersion of Ibuprofen : mannitol-urea gave satisfactory results.