Preparation and In Vitro Evaluation of Biodegradable Microspheres with Narrow Size Distribution for Pulmonary Delivery
School of Food and Chemical Engineering, Beijing Engineering and Technology Research Center of Food Additives, Beijing Higher Institution Engineering Research Center of food additives and Ingredients, Beijing Key Laboratory of Flavor Chemistry, Beijing Technology and Business University, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
Department of Chemical Engineering, Tsinghua University, Beijing 100084, China, E-mail: [email protected]
This study was performed to evaluate the feasibility of double emulsion technique combined with membrane emulsification to prepare microspheres for pulmonary delivery. An attempt was made to counter the shortcomings of microspheres; unsuitable size diameters and broad size distribution. Three formulation variables were optimized in order to achieve desired particle size and narrow size distribution. Compared with microspheres prepared by conventional double emulsion technique, the microsphere morphology, aerodynamic particle size, drug encapsulation efficiency and in vitro release were characterized in detail. The particles prepared by double emulsion technique combined with membrane emulsification showed the advantage on controlling the particle size to meet the requirement of respiration, as well as on encapsulation efficiency. Overall, this strategy could be promising for the application of pulmonary delivery.