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Abstract

Search for antiviral agents : synthesis of sulphonyl biguanides.

Author(s): S Prakash
Dept. of Chemistry, University of Zambia, P.O.Box 32379, LUSAKA, Zambia,

Correspondence Address:
S Prakash Dept. of Chemistry, University of Zambia, P.O.Box 32379, LUSAKA, Zambia

Synthesis and antiviral activity of fifteen new N1 - (morpholino/piperidino/pyrrolidino-N-sulphonyl)-N5-aryl biguanide hydrochlorides is reported. These compounds (10 mg/ml) showed 20-30 percent inhibition of Tobacco Mosaic virus in the test system.