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Abstract

Sevron Blue 5G As An Ion-Pairing Reagent For The Determination Of Acidic Drugs In Pharmaceutical Formulations

Author(s): C. S. P Sastry, K Rama Srinivas, K. M. M Krishna Prasad

An extractive spectrophotometric technique was applied for the determination of four acidic drugs, viz., Piroxicam, Sulphinphyrazone, Frusemide and Trichlormethazide using an oxazine dye, Sevron blue 5G as reagent. The method of the determination is based on the measurement of the absorbance of the chloroform extract of the ion-association complex formed between the drug and the dye at pH 7.0, which exhibits an absorption maximum at 655 nm. The method is simple, rapid sensitive, reproducible and with an accuracy of ± 1%.