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Abstract

Simultaneous spectrophotometric determination of amlodipine besylate and atorvastatin calcium in binary mixture

Author(s): R Sahu, Vandana B Patel
Quality Assurance Laboratory, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, India

Correspondence Address:
Vandana B Patel Quality Assurance Laboratory, Pharmacy Department, The Maharaja Sayajirao University of Baroda, Vadodara India E-mail: [email protected]


A rapid, simple, accurate and precise UV Spectrophotometric method using simultaneous equation was developed for the simultaneous determination of amlodipine besylate and atorvastatin calcium in a binary mixture. In the proposed method, the signals were measured at 238.2 and 246.6 nm corresponding to the absorbance maxima of amlodipine besylate and atorvastatin calcium in methanol, respectively. Linearity was observed in the concentration range of 5-30 µg/ml for both the drugs. Concentration of each drug was obtained by using the absorptivity values calculated for both the drugs at two wavelengths, 238.2 and 246.6 nm and solving the simultaneous equations. The method was validated statistically and recovery study was performed to confirm the accuracy of the method. Laboratory prepared synthetic mixture was successfully analyzed using the developed method.



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