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Abstract

Spectrophotometric determination of sulphacetamide sodium with o-chloranil in dosage forms.

Author(s): GR Rao, S SN Murty, PJ Rao, I RK Raju, Rao G Rama, R ao Jagannadha
Quality Control Laboratories, I.D.P.L., Hyderabad-500 037,

Correspondence Address:
G R Rao Quality Control Laboratories, I.D.P.L., Hyderabad-500 037

A spectrophotometric method for the estimation of sulphacetamide based on its reaction with o-Chloranil at pH 9.0 yielding a purple coloured chromogen with absorption maximum at 525 nm is reported. Beer's law is obeyed over the concentration range 10 to 70 mug/ml of sulphacetamide sodium. The proposed method is applicable to pharmaceutical preparations.