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Abstract

Spectrophotometric Estimation Of Pyrantel In Pharmaceutical Formulations

Author(s): C. S. R Lakshmi, M. N Reddy

Four simple and sensitive visible spectrophotometric methods have been described for the determination of pyrantel based on the formation of coloured charge-transfer complex between drug and chloranilic acid (method A, λmax : 540 nm) or by the reduction of Folin-Ciocalteau reagent (method B, λmax : 760 nm) or by finding the oxidant [N-bromosuccinimide (NBS) or potassium permanganate (KmnO4)] reacted with pyrantel using a dye [celestine blue λmax : 540 nm (method C) or cresyl fast violet acetate λmax : 600 nm (method D)]. The results obtained are reproducible with coefficient of variation of less than 1.0%.