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Abstract

Spectrophotometric estimation of raltegravir potassium in tablets

Author(s): PP Kore, MM Gamepatil, HM Nimje, KG Baheti
Department of Pharmaceutical Chemistry, Charak College of Pharmacy and Research, Wagholi, Pune-412 207, India

Correspondence Address:
K G Baheti Department of Pharmaceutical Chemistry, Charak College of Pharmacy and Research, Wagholi, Pune-412 207 India E-mail: [email protected]


Ultra violet spectrophotometric estimation of the raltegravir potassium, an integrase inhibitor antiretroviral agent was estimated by Ultra violet absorption maxima method at λmax of 328 nm and UV area under curve method in the wave length range of 323-333 nm. The Beer's law obeyed in the concentration range of 3-55 μg/ml and correlation coefficients were found to be more than 0.996 for both methods. The results of the analysis were 100.58±0.99 and 99.69±0.59 by absorption maxima and area under curve method respectively. Both the methods were validated as per ICH guidelines.



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