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Abstract

Spectrophotometric Estimation Of Venlafaxine With Folin Ciocalteu Reagent

Author(s): A Rajasekaran, M Arulkumaran, S Kannanraj

A simple, rapid, precise, accurate and highly specific spectrophotometric method has been developed for the determination of venlafaxine in its pharmaceutical dosage form. The method is based on the formation of blue colored chromogen due to the reaction of venlafaxine with Folin Ciocalteu reagent in presence of alkali, which exhibits λmax at 730 nm. Beer's law obeyed in the concentration range of 2.5-25 μg/ml. The blue color obtained was stable for more than 24 hours. The method was successfully applied for the quantitative determination of venlafaxine and its pharmaceutical dosage form. The accuracy and reproducibility of the proposed method was statistically validated by recovery studies.