Study on the bio-availability of naproxen from compressed suppositories and comparison with suspension in rabbits.
Pharmacology Section, Indian Institute of Chemical Technology,
M SP Sastry Pharmacology Section, Indian Institute of Chemical Technology
Compressed 25 mg suppositories of naproxen, suitable to tropical were formulated and evaluated for bio-availability and other pharmacokinetic parameters and the results were compared with those of suspension in rabbits. Different pharmacokinetic parameters after oral and rectal administration of naproxen were calculated using a model independent computer program "RAMKIN". The differences in pharmacokinetic parameters, c max,AUC-24h, t1/2 and MRT obtained after oral and rectal administration of naproxen were statistically insignificant (P>0.05) revealing good performance of the compressed suppositories of naproxen. Absorption was faster from suspension as can be expected. Results indicated bio-equivalence of naproxen from compressed supositories and suspension.