Abstract

Synthesis and antibacterial activity of 2-(2,4-dinitrophenyl)-3,5-diphenyl (substituted)-6-aryl-3,3a,5,6-tetrahydro-2H-pyrazolo[3,4-d] thiazoles

Author(s): SK Sahu1, SK Mishra1, RK Mohanta1, SP Pattanayak1, CS Panda2
1 University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar-751 004, India 2 P. G. Department of Chemistry, Behrampur University, Behrampur-760 007, India

Correspondence Address:
S K Sahu University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar-751 004 India E-mail: [email protected]


Condensation of substituted benzaldehydes with primary aryl amines gave a series of Schiff bases(1a 1 -e 1 ,a 2 ,b 2 ,d 2 ,b 3 -e 3 ) which, on reaction with thioglycolic acid, resulted in the formation of the corresponding 4-thiazolidinones(2a 1 -e 1 ,a 2 ,b 2 ,d 2 ,b 3 -e 3 ). These compounds, on condensation with substituted benzaldehydes in anhydrous sodium acetate, furnished 2-phenyl(substituted)-3-aryl-5-benzilidine(substituted)-thiazolidine-4-ones(3a 1 -e 1 ,a 2 ,b 2 ,d 2 , b 3 -e 3 ). The latter, on heating with 2,4-dinitrophenyl hydrazine in anhydrous sodium acetate, gave the title compounds(4a 1 -e 1 ,a 2 ,b 2 ,d 2 ,b 3 -e 3 ). The structures have been established on the basis of elemental analysis and spectral data. The title compounds have been screened in vitro for their possible antibacterial activity



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