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Abstract

Synthesis and in vitro amoebicdal activity of some n, n'-disubstituted diamines

Author(s): PL Kachroo, R Gupta, R Wadhawan
Dept. of Chemistry, University of Jammu, Jammu 180 001

Correspondence Address:
P L Kachroo Dept. of Chemistry, University of Jammu, Jammu 180 001

Eighteen N, N'-di[3-(2,4-dialkoxy-5-alkylphenyl) propyl]-1,2 ethane; 1,4-butane and 1,4-benzene diamines have been synthesised by condensation of 2,4-dialkoxy-5-alkylbenzenepropanoyl chlorides with 1,2-diamino ethane, 1,4-di-aminobutane and 1,4-diaminobenzene followed by reduction of the diamides with LAH. the diamine dihydrochlorides have been tested in vitro for amoebicidal activity against E. histolytica.